Senior Research Fellow
1992-2007 University of NSW
2007-present University of Sydney
Karren holds a Bachelor of Science degree majoring in Biochemistry and Cell Pathology from the University of Sydney and completed her PhD from the University of NSW focused on T cell responses in transplantation tolerance. Prior to joining the Farm Animal and Veterinary Public Health group as a research fellow in 2007, she was the co-chief investigator on a grant examining the role of cytokines in transplantation tolerance. Her work involves developing new diagnostic tools to enable accurate determination of infection status, the analysis of the host/pathogen interaction in Johne’s disease and identification of genetic resistance traits.
Interests include understanding how the immune response is controlled in chronic infectious diseases. Without control, an immune response that is meant to protect the host may damage the normal tissues in the body. These principles have been applied to the study of Johne’s disease in sheep and cattle, a chronic disease where the infectious organism attempts to evade immune attack. One form of evasion may be by harnessing of immune regulatory mechanisms that have evolved to protect the host.